Courses and teaching tools

Genomic Thinking

The course introduces key concepts in population genomics from generation of population genetic data sets to the most common population genetic analyses and association studies. The first part of the course focuses on generation of population genetic data sets. The second part introduces the most common population genetic analyses and their theoretical background. Here, topics include analysis of demography, population structure, recombination and selection. The last part of the course focus on applications of population genetic data sets for association studies in relation to human health.

Tools and Resources:

Bioinformatics

The course introduces programming and its practical applications in bioinformatics. The course also outlines and discusses bioinformatics algorithms and the most common tools for bioinformatics analysis of sequence data are presented and demonstrated. During the first seven weeks the participant will aquire and train basic programming skills. The last seven weeks introduce key topics in bioinformatics with focus on application of bioinformatical software and aquired programming skills. Subjects for lectures and exercises include: bioinformatics databases, sequence alignment, genome annotation, sequence evolution, phylogenetic analysis. See the course website for more information.

Tools and Resources

  • The course and lecture notes are available on GitHub. Feel free to reuse.
  • print-steps is a utility that prints each step by which a Python expression reduces to a single value.
  • myiagi is a terminal GUI game that lets students train substitution and reduction in Python expressions.
  • nnwidgets use a series of interactive widgets that present the student with visual proof that a neural network can represent any function.
  • plotwidgets is a Python widget that adds a GUI to seaborn visualisations and plots.

Past student projects

Student projects include Project in Bioinformatics and Master project. Past student projects in the group:

  • Detection of Selection in the Tumour Suppressor Cluster 3p21.3
  • A composite of multiple signals reveals signatures of positive selection in the 3p21.31 region of East Asians
  • Differential circRNA expression
  • Explorative analysis of X chromosome diversity in Sub-Saharan Africa populations
  • Analysis of positive selection in great ape evolution
  • Differential circRNA expression
  • Profiling circRNA in spermatogenesis
  • Forward simulation of meiotic drive
  • Positive selection on the X chromosome
  • Chromatin structure through spermatogenesis
  • Bayesian inference of A/B compartment borders
  • Characterization of genome properties arround A/B compartment borders.
  • Analysis if Human Accelerated Regions (HARs)